Clinical pharmacology of hexachlorophene in newborn infants.
Bathing with soap containing hexachlorophene was instituted during two major staphylococcal epidemics in a Neonatal Intensive Care Unit. Infants who weighed less than 1,200 gm, those with a postconceptional age of less than 35 weeks, and those with large areas of abraded skin were at highest risk to achieve elevated blood HCP concentrations. T 1/2 of HCP ranged from 6.1 to 44.2 hours and appeared to follow first order kinetics. Time of peak blood concentrations of HCP following a bath ranged from 6 to 10 hours. One infant with liver disease achieved a concentration of HCP of 4,350 ng/ml after seven baths and developed clinical symptoms consistent with HCP toxicity.[1]References
- Clinical pharmacology of hexachlorophene in newborn infants. Tyrala, E.E., Hillman, L.S., Hillman, R.E., Dodson, W.E. J. Pediatr. (1977) [Pubmed]
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