Colorimetric assay of noramidopyrine methanesulfonate sodium in formulations and in blood and urine samples.
A simple, rapid, specific and sensitive colorimetric method is proposed for the quantitative estimation of noramido-pyrine methanesulfonate sodium in different dosage forms as well as in blood and urine samples. The method is based on the reaction of 3-sulfonic-5-amino-alpha-naphthol with formaldehyde liberated from noramidopyrine methanesulfonate sodium after treatment with conc. sulfuric acid where a yellow colour appeared immediately which turned to blue on dilution with water. The blue colour obeyed Beer's law (10--400 microgram) and remained stable for more than 1 h. The effect of other drugs, tablet excipients, parentral vehicles and suppository bases was studied.[1]References
- Colorimetric assay of noramidopyrine methanesulfonate sodium in formulations and in blood and urine samples. Diab, A.H. Die Pharmazie. (1977) [Pubmed]
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