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Reeve, V.E. et al.

Cis-urocanic-acid-induced suppression of contact hypersensitivity in Monodelphis domestica is prevented by ultraviolet A radiation/photoreactivating light.

The suppression of contact hypersensitivity by UVB (280-320 nm) radiation can be prevented by photoreactivating light ( PRL; 320-400 nm) in the opossum Monodelphis domestica, implicating epidermal DNA lesions as the immunosuppressive impairment. However, contact hypersensitivity can also be suppressed in the opossum with exogenous cis-urocanic acid, a molecule which is produced in UVB-irradiated epidermis and is a second potential mediator of photo-immunosuppression apparently independent of UVB-induced DNA damage. Here we demonstrate that irradiation of opossums with PRL either before or following treatment with exogenous cis-urocanic acid, significantly reduced the degree of immunosuppression. This suggests that, in addition to its capacity to initiate post-UVB-exposure epidermal DNA repair, the PRL waveband can induce an immunoprotective product, as yet unidentified, in opossum epidermis.[1]

References

Cis-urocanic-acid-induced suppression of contact hypersensitivity in Monodelphis domestica is prevented by ultraviolet A radiation/photoreactivating light. Reeve, V.E., Ley, R.D. Int. Arch. Allergy Immunol. (1997) [Pubmed]

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