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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Association between the cannabinoid receptor gene (CNR1) and the P300 event-related potential.

In our prior study we observed a significant association between homozygosity for the > or = alleles of a microsatellite polymorphism of cannabinoid receptor genes (CNR1) and drug dependence. Decreased amplitude of the P300 wave of evoked related potentials ( ERP) has long been shown to be associated with alcohol and drug dependence. The P300 wave reflects attentional resource allocation and active working memory. Since marijuana intoxication has a potent blocking effect on short-term memory we examined the association between the CNR1 alleles and the P300 wave amplitude at three electrodes in 35 alcohol and drug addicts, by MANOVA. There was a significant decrease in amplitude of the P300 wave for all three electrodes (P = 0.028) that was most marked for the frontal lobes (P = 0.008) in subjects homozygous for the CNR1 > or = 5 repeat alleles. Multivariate regression analysis indicated the CNR1 gene contributed to 20% of the variance of the frontal lobe P300 wave amplitude.[1]

References

  1. Association between the cannabinoid receptor gene (CNR1) and the P300 event-related potential. Johnson, J.P., Muhleman, D., MacMurray, J., Gade, R., Verde, R., Ask, M., Kelley, J., Comings, D.E. Mol. Psychiatry (1997) [Pubmed]
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