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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens.

TCR gamma delta T cells are considered important in the rapid immune response to intracellular infection. We investigated the early response of peripheral blood gamma delta T cells to the nonpeptide Ag isopentenyl pyrophosphate and to its synthetic analogue ethyl pyrophosphate. In healthy donors, an increase in the number of gamma delta T cells was detected as soon as 4 days after stimulation with the nonpeptide Ags. Single-cell analysis of cytokine production was performed by intracellular staining of IFN-gamma and IL-4. gamma delta T cells were found to rapidly expand and produce IFN-gamma in response to nonpeptide Ags. Furthermore, IL-12 augmented the IFN-gamma response. In contrast, gamma delta T cells from the majority of HIV+ donors did not expand or express IFN-gamma in response to nonpeptide Ags, even in the presence of IL-12. These findings indicate a role for nonpeptide-reactive gamma delta T cells in effective cell-mediated immunity for intracellular pathogens.[1]

References

  1. Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens. García, V.E., Sieling, P.A., Gong, J., Barnes, P.F., Uyemura, K., Tanaka, Y., Bloom, B.R., Morita, C.T., Modlin, R.L. J. Immunol. (1997) [Pubmed]
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