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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Disruption of the Bcl6 gene results in an impaired germinal center formation.
The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B celllymphomas, and its products are expressed highly in germinal center (GC) B cells. To investigate the function of Bcl6 in lymphocytes, we have generated RAG1-deficient mice reconstituted with bone marrow cells from Bcl6-deficient mice (Bcl6(-/-)RM). Lymphogenesis in primary lymphoid tissues of Bcl6(-/-)RM is normal, and Bcl6(-/-)RM produced control levels of primary IgG1 antibodies specific to T cell-dependent antigens. However, GCs were not found in these mice. This defect was mainly due to the abnormalities of B cells. Therefore, Bcl6 is essential for the differentiation of GC B cells.[1]
