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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins.

The production of epsilon-pyrromycinone glycosides in Streptomyces galilaeus increased 12-fold, with respect to the wild strain, as a result of a sequential procedure including both natural selection and treatment with mutagens (nitrous acid, UV light and gamma-irradiation). Nitrous acid exhibited the highest mutagenic effect, both in increasing the productivity and in inducing blocked mutants. A mutant strain blocked in the biosynthesis of glycosides and accumulating free epsilon-pyrromycinone as the principal metabolite was obtained.[1]

References

  1. Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins. Královocová, E., Blumauerová, M., Vanĕk, Z. Folia Microbiol. (Praha) (1977) [Pubmed]
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