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Virtanen, K.A. et al.

Virtanen, Rouru, Hänninen, Savontaus, Rouvari, Teirmaa, Koulu, Huupponen,

Chronic treatment with BRL 35135 potentiates the action of insulin on lipid metabolism.

The effects of a beta 3-adrenoceptor agonist on insulin-induced changes in lipid metabolism were studied in obese male Zucker (fa/fa) rats during euglycaemic clamp. Rats were treated with BRL 35135 (R*, R*-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl)-ethyl-amino]-propyl] phenoxyacetate hydrobromide) (0.5 mg/kg per day in drinking water) for three weeks before an euglycaemic hyperinsulinaemic clamp was performed. Insulin infusion lowered serum non-esterified fatty acids and plasma glycerol more efficiently in BRL 35135-treated than in control rats although plasma insulin remained significantly lower in the BRL 35135-treated than in the control rats during the clamp. In conclusion, chronic treatment with BRL 35135 potentiates the effect of insulin on lipid metabolism.[1]

References

Chronic treatment with BRL 35135 potentiates the action of insulin on lipid metabolism. Virtanen, K.A., Rouru, J., Hänninen, V., Savontaus, E., Rouvari, T., Teirmaa, T., Koulu, M., Huupponen, R. Eur. J. Pharmacol. (1997) [Pubmed]

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