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Kuzumaki, T. et al.

Kuzumaki, Ishikawa,

Loss of cell adhesion to substratum up-regulates p21Cip1/WAF1 expression in BALB/c 3T3 fibroblasts.

Cell adhesion to substratum is essential for the transition of G1 to S phase in mouse BALB/c 3T3 fibroblast cell cycle. Loss of cell adhesion in late G1 phase caused blockage of the G1/S phase transition and repression of cyclin E- associated cyclin-dependent kinase-2 (CDK2) activity. A CDK2 inhibitor abundant in quiescent cells, p27Kip1, was down-regulated by growth factors in serum, and this down-regulation was partially prevented by loss of cell adhesion. Another CDK2 inhibitor, p21Cip1/WAF1, which was undetectable in quiescent cells, was markedly induced by loss of cell adhesion. In exponentially growing cells, loss of cell adhesion also induced p21Cip1/WAF1 expression but did not affect the abundance of p27Kip1. These results suggest that loss of cell adhesion to substratum up-regulates p21Cip1/WAF1 expression, which plays an essential role for arresting the BALB/c 3T3 fibroblast cell cycle.[1]

References

Loss of cell adhesion to substratum up-regulates p21Cip1/WAF1 expression in BALB/c 3T3 fibroblasts. Kuzumaki, T., Ishikawa, K. Biochem. Biophys. Res. Commun. (1997) [Pubmed]

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