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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa.

Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.[1]

References

  1. Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa. Köhler, T., Michea-Hamzehpour, M., Plesiat, P., Kahr, A.L., Pechere, J.C. Antimicrob. Agents Chemother. (1997) [Pubmed]
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