Tissue specific control regions of the N-methyl-D-aspartate receptor subunit NR2C promoter.
In the mouse brain, the N-methyl-D-aspartate receptor subunit NR2C (epsilon-3) is mainly detected in the cerebellar granule cells starting from the second week of postnatal life. In order to improve our understanding of molecular mechanisms of this neuron-specific, spatial and temporal gene expression, different promoter fragments were used to control indicator genes in nondifferentiated rat pheochromocytoma (PC12) cells, in human embryonal kidney (HEK293) cells and in transgenic mice. A 400 bp NR2C promoter region upstream of the transcriptional start site was identified as a basal promoter that was negatively regulated possibly by a neuron restrictive silencer element (NRSE) that is localized 664 base pairs downstream from the transcriptional start sites.[1]References
- Tissue specific control regions of the N-methyl-D-aspartate receptor subunit NR2C promoter. Suchanek, B., Seeburg, P.H., Sprengel, R. Biol. Chem. (1997) [Pubmed]
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