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Severe granulocytopenia secondary to chlorpromazine despite concurrent lithium treatment: a case report.

Severe chlorpromazine-induced granulocytopenia where the white-cell count decreases to below 1,000/mm3 rarely occurs and lithium is known to cause leucocytosis. The use of lithium in the prevention of granulocytopenia induced by drugs is still controversial. This report describes a patient with bipolar disorder suffering from severe granulocytopenia and severe respiratory infection after receiving chlorpromazine 50 to 150 mg per day along with long term lithium therapy. Bone-marrow aspiration and biopsy revealed inhibited maturation of myeloid series in the promyelocyte stage. The findings were consistent with a drug-induced effect. White-cell count return to normal after the discontinuation of chlorpromazine. It was proved in this case that combined lithium therapy had no effect in preventing agranulocytosis induced by chlorpromazine.[1]

References

  1. Severe granulocytopenia secondary to chlorpromazine despite concurrent lithium treatment: a case report. Yen, C.F., Chong, M.Y., Kuo, M.C., Chang, C.S. The Kaohsiung journal of medical sciences. (1997) [Pubmed]
 
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