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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins.

Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/ Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/ Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a member of the CDC4 family of proteins and has a potential human ortholog. Coimmunoprecipitation data indicate that C. elegans SEL-10 complexes with LIN-12 and with murine Notch4. We propose that SEL-10 promotes the ubiquitin- mediated turnover of LIN-12/ Notch proteins, and discuss potential roles for the regulation of lin-12/ Notch activity by sel-10 in cell fate decisions and tumorigenesis.[1]

References

  1. sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Hubbard, E.J., Wu, G., Kitajewski, J., Greenwald, I. Genes Dev. (1997) [Pubmed]
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