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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Vasculitis and bronchiectasis in a patient with antibodies to bactericidal/permeability-increasing protein and alpha1-antitrypsin deficiency.

A patient with alpha1-antitrypsin deficiency is reported herein; this subject developed aggressive bronchial disease and recurrent cutaneous vasculitis after pulmonary infection with Pseudomonas aeruginosa. Autoantibodies to neutrophil cytoplasmic antigens were detected, which produced granular cytoplasmic staining by indirect immunofluorescence with specificity for a newly characterized antigen: bactericidal/permeability-increasing protein ( BPI). The bronchial disease and vasculitis improved, and the IgA anti- BPI titer fell after antipseudomonal treatment. This raises the possibility that anti- BPI antibodies contributed to both the bronchial disease and vasculitis.[1]

References

  1. Vasculitis and bronchiectasis in a patient with antibodies to bactericidal/permeability-increasing protein and alpha1-antitrypsin deficiency. Mahadeva, R., Zhao, M.H., Stewart, S., Cary, N., Flower, C., Lockwood, M., Shneerson, J. Chest (1997) [Pubmed]
 
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