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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Optimisation of the enantiomeric separation of 12 2-aminotetralin analogues using Chiral AGP high-performance liquid chromatography by simultaneous factorial design.

A method for the simultaneous optimisation of mobile phase composition for the resolution of pairs of enantiomers of 12 2-aminotetralin analogues is presented. The selectivity necessary to discriminate between 12 analytes was obtained by using mass selective detection. The ability to examine more than a few analytes at a time extends the otherwise limited applicability of a factorial design strategy to the rapid development of chiral assays.[1]

References

  1. Optimisation of the enantiomeric separation of 12 2-aminotetralin analogues using Chiral AGP high-performance liquid chromatography by simultaneous factorial design. Wood, S.A., Long, J.M., Simmonds, R.J., Bridges, J.W., Stevenson, D. Journal of pharmaceutical and biomedical analysis. (1997) [Pubmed]
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