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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Formation of 8-hydroxyguanine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine in DNA by riboflavin mediated photosensitization.

Calf thymus DNA was photoirradiated in the presence of riboflavin. Altered bases were detected and quantified by the GC/MS-SIM method after hydrolysis and derivatization of DNA. Seven types of modified purine bases were detected in control DNA. Among them, the yields of 8-OH-Gua and FapyGua increased significantly in DNA photo-irradiated with riboflavin, whereas the yields of xanthine, 8-OH-Ade, 2-OH-Ade, FapyAde and hypoxanthine were not affected. A dose dependent increase in the formation of 8-OH-Gua was observed with increasing riboflavin concentration for 30 min irradiation. On the other hand, FapyGua reached plateau at 10 micrograms/ml of riboflavin for 30 min irradiation. Our results indicate that guanine moiety in DNA is the most susceptible to riboflavin mediated photosensitization.[1]

References

  1. Formation of 8-hydroxyguanine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine in DNA by riboflavin mediated photosensitization. Mori, T., Tano, K., Takimoto, K., Utsumi, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
 
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