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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution.

DNA polymerases change their specificity for nucleotide substrates with each catalytic cycle, while achieving error frequencies in the range of 10(-5) to 10(-6). Here we present a 2.2 A crystal structure of the replicative DNA polymerase from bacteriophage T7 complexed with a primer-template and a nucleoside triphosphate in the polymerase active site. The structure illustrates how nucleotides are selected in a template-directed manner, and provides a structural basis for a metal-assisted mechanism of phosphoryl transfer by a large group of related polymerases.[1]

References

  1. Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution. Doublié, S., Tabor, S., Long, A.M., Richardson, C.C., Ellenberger, T. Nature (1998) [Pubmed]
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