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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Ionophoretic properties of ferutinin.

The influence of the natural terpenoid ferutinin (4-oxy-6-(4-oxybenzoyloxy) dauc-8,9-en), isolated from the plant Ferula tenuisecta, on ion permeability of biological and artificial membranes was investigated. It was shown that ferutinin, in the concentration range 1-50 microM, increases the permeability of thymocytes, mitochondria, sarcoplasmic reticulum, liposomes and bilayer lipid membranes (BLM) for Ca2+. Ferutinin establishes a transmembrane potential in BLM equal to the Nernst's potential. The permeability ratio for Na+/Ca2+ is 0.41. The dependence of BLM conductivity on ferutinin concentration is linear. The stoichiometry of the ferutinin:Ca2+ complex is 2, assuming the formation of a structure with participation of two terpenoid molecules and one Ca2+ ion.[1]

References

  1. Ionophoretic properties of ferutinin. Zamaraeva, M.V., Hagelgans, A.I., Abramov, A.Y., Ternovsky, V.I., Merzlyak, P.G., Tashmukhamedov, B.A., Saidkhodzjaev, A.I. Cell Calcium (1997) [Pubmed]
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