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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Serum levels of human placental lactogen, pregnancy-associated plasma protein A and endometrial secretory protein PP14 in first trimester of diabetic pregnancy.

OBJECTIVE: To study maternal serum levels of human placental lactogen (hPL), pregnancy-associated plasma protein A (PAPP-A) and endometrial secretory protein PP14 ( PP14) in first trimester of diabetic pregnancy. METHODS: Seventy-nine insulin-dependent diabetic women and 93 normal pregnant women had a venous blood sample drawn in weeks 8-14, ultrasound age. Serum levels were measured by radioimmunoassays and expressed in multiples of the median serum value in normal pregnancy at that ultrasound age. RESULTS: Levels of hPL were significantly lower in diabetic mothers than in controls, z'= -5.502, p<0.00001. Levels of PAPP-A were also significantly lower, z' =2.263, p=0.024, but were significantly less depressed than those of hPL, z'=2.41, p=0.015. The PP14 levels did not deviate from normal. CONCLUSION: In first trimester of diabetic pregnancy there appears to be both a more general depression of trophoblast function, and also a specific depression of the hPL release.[1]

References

  1. Serum levels of human placental lactogen, pregnancy-associated plasma protein A and endometrial secretory protein PP14 in first trimester of diabetic pregnancy. Pedersen, J.F., Sørensen, S., Mølsted-Pedersen, L. Acta obstetricia et gynecologica Scandinavica. (1998) [Pubmed]
 
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