Embryonic implantation in galectin 1/galectin 3 double mutant mice.
Galectin 1 and galectin 3 are first expressed in the trophectoderm cells of the implanting embryo and have been implicated in the process of implantation. However, we had previously shown that the lack of galectin 1 in galectin 1 null mutant mice is compatible with implantation. In this study, we describe the generation of galectin 3 null mutant mice and show that they are viable and have no overt abnormalities. The importance of galectin 1 and galectin 3 in implantation was assessed by obtaining double mutant mice [gal1 -/-; gal3 -/-]. We find that implantation can still occur in the absence of both galectin 1 and galectin 3. However, we show that galectin 5, a third member of this gene family, is also present in the blastocyst at the time of implantation.[1]References
- Embryonic implantation in galectin 1/galectin 3 double mutant mice. Colnot, C., Fowlis, D., Ripoche, M.A., Bouchaert, I., Poirier, F. Dev. Dyn. (1998) [Pubmed]
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