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Martín-Burriel, I. et al.

Martín-Burriel, Goldammer, Elduque, Lundin, Barendse, Zaragoza, Olsaker,

Physical and linkage mapping of the bovine bone morphogenetic protein 1 on the evolutionary break region of BTA 8.

Bone morphogenetic protein 1 ( BMP1) has been proposed as a regulatory molecule involved in the binding or activation of other BMP molecules. It has been described as being identical to the enzyme C-proteinase that processes procollagens to fibrillar collagens. A fragment containing an exon of the bovine BMP1 gene was amplified from an adapter-ligated genomic DNA library. The isolated bovine BMP1 fragment was assigned by fluorescence in situ hybridization (FISH) to bovine (BTA) chromosome 8q21, a region containing an evolutionary breakpoint between homology to human (HSA) chromosomes 8 and 9. The assignment to BTA 8 was confirmed by using a hybrid somatic cell panel. The 3' intron region of the amplified genomic BMP1 fragment showed a SSCP polymorphism, and linkage analysis in the International Bovine Reference Panel (IBRP) of families confirmed the boundary position of this gene. The BMP1 gene presents total linkage (theta = 0.00, Z = 3.61) with the lipoprotein lipase gene on BTA 8 and HSA 8 and a larger recombination fraction (theta = 0.11, Z = 5.03) with the marker GGTB2 on BTA 8 and HSA 9. Physical and genetic mapping of the bovine BMP1 gene contribute to narrow the boundary between the HSA 8 and HSA 9 homology segments on BTA 8 and to the comparative mapping between BTA 8, murine chromosome MMU 14, and HSA 8.[1]

References

Physical and linkage mapping of the bovine bone morphogenetic protein 1 on the evolutionary break region of BTA 8. Martín-Burriel, I., Goldammer, T., Elduque, C., Lundin, M., Barendse, W., Zaragoza, P., Olsaker, I. Cytogenet. Cell Genet. (1997) [Pubmed]

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