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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Nitrofurantoin-induced hepatotoxicity mediated by CD8+ T cells.

Nitrofurantoin is a synthetic nitrofuran commonly used for the treatment and prophylaxis of urinary tract infections. We describe the case of a 75-yr-old woman who was taking nitrofurantoin as prophylaxis against recurrent urinary tract infections, and who subsequently developed pulmonary and hepatic toxicity. We postulate that a breakdown product of the drug or the drug itself complexed to an endogenous peptide is presented by the class I HLA antigen on the hepatocyte cell membrane, inducing cytotoxic T cell activation and subsequently, hepatocyte death.[1]

References

  1. Nitrofurantoin-induced hepatotoxicity mediated by CD8+ T cells. Kelly, B.D., Heneghan, M.A., Bennani, F., Connolly, C.E., O'Gorman, T.A. Am. J. Gastroenterol. (1998) [Pubmed]
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