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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Driessen, C.A. et al.

Driessen, Winkens, Kuhlmann, Janssen, van Vugt, Deutman, Janssen,

The visual cycle retinol dehydrogenase: possible involvement in the 9-cis retinoic acid biosynthetic pathway.

The 11-cis-retinol dehydrogenase (11-cis-RoDH) gene encodes the short-chain alcohol dehydrogenase responsible for 11-cis-retinol oxidation in the visual cycle. The structure of the murine 11-cis-RoDH gene was used to reinvestigate its transcription pattern. An 11-cis-RoDH gene transcript was detected in several non-ocular tissues. The question regarding the substrate specificity of the enzyme was therefore addressed. Recombinant 11-cis-RoDH was found capable of oxidizing and reducing 9-cis-, 11-cis- and 13-cis-isomers of retinol and retinaldehyde, respectively. Dodecyl-beta-1-maltoside used to solubilize the enzyme was found to affect the substrate specificity. This is the first report on a visual cycle enzyme also present in non-retinal ocular and non-ocular tissues. A possible role in addition to its role in the visual cycle is being discussed.[1]

References

The visual cycle retinol dehydrogenase: possible involvement in the 9-cis retinoic acid biosynthetic pathway. Driessen, C.A., Winkens, H.J., Kuhlmann, E.D., Janssen, A.P., van Vugt, A.H., Deutman, A.F., Janssen, J.J. FEBS Lett. (1998) [Pubmed]

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