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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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TGF-beta- stimulated cooperation of smad proteins with the coactivators CBP/p300.

TGF-beta and activin induce the phosphorylation and activation of Smad2 and Smad3, but how these proteins stimulate gene transcription is poorly understood. We report that TGF-beta receptor phosphorylation of Smad3 promotes its interaction with the paralogous coactivators CBP and p300, whereas CBP/p300 binding to nonphosphorylated Smad3 or its oligomerization partner Smad4 is negatively regulated by Smad-intramolecular interactions. Furthermore, p300 and TGF-beta receptor- phosphorylated Smad3 synergistically augment transcriptional activation. Thus, CBP/p300 are important components of activin/TGF-beta signaling and may mediate the antioncogenic functions of Smad2 and Smad4.[1]

References

  1. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Janknecht, R., Wells, N.J., Hunter, T. Genes Dev. (1998) [Pubmed]
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