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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Pim-1 kinase and p100 cooperate to enhance c-Myb activity.

The pim-1 oncogene is regulated by hematopoietic cytokine receptors, encodes a serine/threonine protein kinase, and cooperates with c-myc in lymphoid cell transformation. Using a yeast two-hybrid screen, we found that Pim-1 protein binds to p100, a transcriptional coactivator that interacts with the c-Myb transcription factor. Pim-1 phosphorylated p100 in vitro, formed a stable complex with p100 in animal cells, and functioned downstream of Ras to stimulate c-Myb transcriptional activity in a p100-dependent manner. Thus, Pim-1 and p100 appear to be components of a novel signal transduction pathway affecting c-Myb activity, linking all three to the cytokine-regulated control of hematopoietic cell growth, differentiation, and apoptosis.[1]

References

  1. Pim-1 kinase and p100 cooperate to enhance c-Myb activity. Leverson, J.D., Koskinen, P.J., Orrico, F.C., Rainio, E.M., Jalkanen, K.J., Dash, A.B., Eisenman, R.N., Ness, S.A. Mol. Cell (1998) [Pubmed]
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