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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A novel super-potent neurokinin A receptor antagonist containing dehydroalanine.

We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity. Its pharmacological properties as a neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and were compared to those of Neuronorm and MEN10627.[1]

References

  1. A novel super-potent neurokinin A receptor antagonist containing dehydroalanine. Lombardi, A., D'Agostino, B., Nastri, F., D'Andrea, L.D., Filippelli, A., Falciani, M., Rossi, F., Pavone, V. Bioorg. Med. Chem. Lett. (1998) [Pubmed]
 
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