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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Transplacental induction of lymphomas in Swiss mice by carbendazim and sodium nitrite.

Swiss mice at different stages of pregnancy were treated intragastrically with the pesticide Carbendazim ( MBC, BCM, methyl-2-benzimidazole carbamate) together with sodium nitrite. Lymphomas developed in 33.3% of young mice whose mothers were treated in the first week of pregnancy, in 53.3% of whose mothers were treated during the second week, and in 38.8% of those born of mothers treated during the third week. Treatment during the whole period of pregnancy yielded on an average 70.0% malignancy in offspring. However, administration of Carbendazim by itself did not produce lymphomas in the first generation. In lymphomas induced by in vivo-formed n-nitroso compounds, A- and C-type oncornavirus particles were observed with the electron microscope.[1]

References

  1. Transplacental induction of lymphomas in Swiss mice by carbendazim and sodium nitrite. Börzsönyi, M., Pintér, A., Surján, A., Farkas, I. Int. J. Cancer (1976) [Pubmed]
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