- CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection. Afford, S.C., Randhawa, S., Eliopoulos, A.G., Hubscher, S.G., Young, L.S., Adams, D.H. J. Exp. Med. (1999)