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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans.

Mutations in the C. elegans gene egl-27 cause defects in cell polarity and cell migration: the polarity of the asymmetric T cell division is disrupted and the descendants of the migratory QL neuroblast migrate incorrectly because they fail to express the Hox gene mab-5. Both of these processes are known to be controlled by Wnt pathways. Mosaic analysis indicates that egl-27 function is required in the T cell for proper cell polarity. We cloned egl-27 and discovered that a domain of the predicted EGL-27 protein has similarity to Mta1, a mammalian factor overexpressed in metastatic cells. Overlaps in the phenotypes of egl-27 and Wnt pathway mutants suggest that the EGL-27 protein interacts with Wnt signaling pathways in C. elegans.[1]

References

  1. EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans. Herman, M.A., Ch'ng, Q., Hettenbach, S.M., Ratliff, T.M., Kenyon, C., Herman, R.K. Development (1999) [Pubmed]
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