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Claeysen, S. et al.

5-HT4 receptors: cloning and expression of new splice variants.

On the basis of differences in the potencies and intrinsic activity of 5-HT4 receptor agonists in different biological models it has been suggested that there is heterogeneity among 5-HT4 receptors. Here, we report the molecular cloning of several 5-HT4 receptor splice variants in mouse, rat, and human brain. Our data suggest that the differences in efficacy of 5-HT4 ligands on 5-HT4 receptor-mediated responses in several tissues is due to differences in coupling efficiency rather than to the presence of different 5-HT4 receptor isoforms.[1]

References

5-HT4 receptors: cloning and expression of new splice variants. Claeysen, S., Faye, P., Sebben, M., Taviaux, S., Bockaert, J., Dumuis, A. Ann. N. Y. Acad. Sci. (1998) [Pubmed]

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