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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas.

The OZF gene encodes a protein consisting of 10 zinc finger motifs and is located on chromosome 19q3. 1. We report here the amplification and over-expression of the OZF gene in pancreatic carcinomas. Increased gene copy number was detected in 3 of 12 tumour cell lines and 2 of 12 primary pancreatic carcinomas. Expression was detected in all cell lines, and the gene was over-expressed in cell lines with OZF gene amplification. Five of 8 tumours, including 2 primary tumours with OZF gene amplification, displayed high levels of OZF protein, whereas normal pancreas expressed low levels. Immuno-histochemical analysis showed that expression was restricted to tumour cells. Thus, high-level expression of OZF is frequent in pancreatic carcinomas and may contribute to the development or progression of this tumour.[1]

References

  1. Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas. Ferbus, D., Fléchon, A., Muleris, M., Li, Y., Hanash, S., Terris, B., Hammel, P., Pibouin, L., Dutrillaux, B., Goubin, G. Int. J. Cancer (1999) [Pubmed]
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