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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Ecto-ATPase activity in cerebellum: implication to the function of synaptic transmission.

The involvement of ATP in synaptic transmission was examined in synapses on granule cells of the rat cerebellum using ecto-ATPase activity. Reaction product was found in a majority but not all synapses between axodendritic, axoaxonic, and dendrodendritic appositions of granule cells and was associated with extracellular surface of both pre- and postsynaptic membranes. Specificity of the detection was justified by using diethyl pyrocarbonate, specific inhibitor of ecto-ATPase activity. These observations provide direct morphological evidence in support of the view that ATP participates in synaptic transmission and indicate functional heterogeneity of synapses in cerebellum.[1]

References

  1. Ecto-ATPase activity in cerebellum: implication to the function of synaptic transmission. Zinchuk, V.S., Okada, T., Kobayashi, T., Seguchi, H. Brain Res. (1999) [Pubmed]
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