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Chemical Compound Review

Grgd peptide     (2S)-2-[2-[[(2S)-2-(2- aminoethanoylamino)...

Synonyms: AC1L2QQO, AR-1J1308, AC1Q5JR0, 97461-81-9, Gly-arg-gly-asp, ...
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High impact information on Gly-arg-gly-asp

  • All three forms of discoidin I, an endogenous N-acetylgalactosamine-binding lectin from D. discoideum, contain the amino acid sequence gly-arg-gly-asp also found in fibronectin and implicated in its attachment to cells [1].
  • Growth of human endothelial cells on photochemically grafted Gly-Arg-Gly-Asp (GRGD) chitosans [2].
  • The results demonstrated that the integrin antagonist, Gly-Arg-Gly-Asp (GRGD), increased the percentage of cells with apoptosis (from 0.9+/-0.5% to 27.2+/-9.9%, P < 0.01) [3].
  • Cell attachment to the gelatin-HA sponge could be blocked by preincubation of cells with a soluble fibronectin peptide Gly-Arg-Gly-Asp (GRGD) [4].
  • Guanidinobenzoatase is a cell surface protease associated with cells capable of migration, this enzyme is trypsin-like and cleaves the link peptide Gly-Arg-Gly-Asp of fibronectin [5].

Associations of Gly-arg-gly-asp with other chemical compounds


  1. Discoidin I is implicated in cell-substratum attachment and ordered cell migration of Dictyostelium discoideum and resembles fibronectin. Springer, W.R., Cooper, D.N., Barondes, S.H. Cell (1984) [Pubmed]
  2. Growth of human endothelial cells on photochemically grafted Gly-Arg-Gly-Asp (GRGD) chitosans. Chung, T.W., Lu, Y.F., Wang, S.S., Lin, Y.S., Chu, S.H. Biomaterials (2002) [Pubmed]
  3. Signaling and regulatory mechanisms of integrinalpha3beta1 on the apoptosis of cultured rat podocytes. Chen, C.A., Tsai, J.C., Su, P.W., Lai, Y.H., Chen, H.C. J. Lab. Clin. Med. (2006) [Pubmed]
  4. Disulfide-crosslinked hyaluronan-gelatin sponge: growth of fibrous tissue in vivo. Liu, Y., Shu, X.Z., Gray, S.D., Prestwich, G.D. Journal of biomedical materials research. Part A. (2004) [Pubmed]
  5. Inhibitors of guanidinobenzoatase and their possible role in cell migration. Steven, F.S., Griffin, M.M. Biol. Chem. Hoppe-Seyler (1988) [Pubmed]
  6. Growth of human endothelial cells on different concentrations of Gly-Arg-Gly-Asp grafted chitosan surface. Chung, T.W., Lu, Y.F., Wang, H.Y., Chen, W.P., Wang, S.S., Lin, Y.S., Chu, S.H. Artificial organs. (2003) [Pubmed]
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