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Chemical Compound Review:

Grgd peptide (2S)-2-[2-[[(2S)-2-(2- aminoethanoylamino)...

Synonyms: AC1L2QQO, AR-1J1308, AC1Q5JR0, 97461-81-9, Gly-arg-gly-asp, ...

Springer, W.R. et al., Steven, F.S. et al., Chen, C.A. et al., Liu, Y. et al., Chung, T.W. et al., et al.

Chung, Lu, Wang, Chen, Wang, Lin, Chu, Chung, Lu, Wang, Lin, Chu,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Gly-arg-gly-asp

All three forms of discoidin I, an endogenous N-acetylgalactosamine-binding lectin from D. discoideum, contain the amino acid sequence gly-arg-gly-asp also found in fibronectin and implicated in its attachment to cells [1].
Growth of human endothelial cells on photochemically grafted Gly-Arg-Gly-Asp (GRGD) chitosans [2].
The results demonstrated that the integrin antagonist, Gly-Arg-Gly-Asp (GRGD), increased the percentage of cells with apoptosis (from 0.9+/-0.5% to 27.2+/-9.9%, P < 0.01) [3].
Cell attachment to the gelatin-HA sponge could be blocked by preincubation of cells with a soluble fibronectin peptide Gly-Arg-Gly-Asp (GRGD) [4].
Guanidinobenzoatase is a cell surface protease associated with cells capable of migration, this enzyme is trypsin-like and cleaves the link peptide Gly-Arg-Gly-Asp of fibronectin [5].

Associations of Gly-arg-gly-asp with other chemical compounds

Growth of human endothelial cells on different concentrations of Gly-Arg-Gly-Asp grafted chitosan surface [6].

References

Discoidin I is implicated in cell-substratum attachment and ordered cell migration of Dictyostelium discoideum and resembles fibronectin. Springer, W.R., Cooper, D.N., Barondes, S.H. Cell (1984) [Pubmed]
Growth of human endothelial cells on photochemically grafted Gly-Arg-Gly-Asp (GRGD) chitosans. Chung, T.W., Lu, Y.F., Wang, S.S., Lin, Y.S., Chu, S.H. Biomaterials (2002) [Pubmed]
Signaling and regulatory mechanisms of integrinalpha3beta1 on the apoptosis of cultured rat podocytes. Chen, C.A., Tsai, J.C., Su, P.W., Lai, Y.H., Chen, H.C. J. Lab. Clin. Med. (2006) [Pubmed]
Disulfide-crosslinked hyaluronan-gelatin sponge: growth of fibrous tissue in vivo. Liu, Y., Shu, X.Z., Gray, S.D., Prestwich, G.D. Journal of biomedical materials research. Part A. (2004) [Pubmed]
Inhibitors of guanidinobenzoatase and their possible role in cell migration. Steven, F.S., Griffin, M.M. Biol. Chem. Hoppe-Seyler (1988) [Pubmed]
Growth of human endothelial cells on different concentrations of Gly-Arg-Gly-Asp grafted chitosan surface. Chung, T.W., Lu, Y.F., Wang, H.Y., Chen, W.P., Wang, S.S., Lin, Y.S., Chu, S.H. Artificial organs. (2003) [Pubmed]

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