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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Trp-Ala     (2S)-2-[[(2R)-2-amino-3-(1H- indol-3...

Synonyms: AC1O52WA
 
 
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High impact information on Trp-Ala

  • When applied to the apical (AP) side of Caco-2 cell monolayers, DSIP was rapidly metabolized (8.2 +/- 1.1% remaining after a 2-hr incubation), affording Trp as the major metabolite and Trp-Ala as a minor metabolite [1].
  • A radically modified heptapeptide agonist, maintaining only the Trp-Ala moiety of the parent [H-D-Phe6,betaAla11,Phe13,Nle14]-peptide amide, and with a very different carboxyl terminal region, has been produced which was potent at BRS3 and essentially had no NMB or GRP receptor activity [2].
  • In this study we describe abrogation of IL-7 driven proliferation and attenuated phosphotyrosine signaling by IL-7(143) (Trp-Ala) and IL-7(143) (Trp-His) in IL-7R expressing T and B leukemia cells [3].

References

  1. Transport and metabolism of delta sleep-inducing peptide in cultured human intestinal epithelial cell monolayers. Augustijns, P.F., Borchardt, R.T. Drug Metab. Dispos. (1995) [Pubmed]
  2. The design of a new potent and selective ligand for the orphan bombesin receptor subtype 3 (BRS3). Boyle, R.G., Humphries, J., Mitchell, T., Showell, G.A., Apaya, R., Iijima, H., Shimada, H., Arai, T., Ueno, H., Usui, Y., Sakaki, T., Wada, E., Wada, K. J. Pept. Sci. (2005) [Pubmed]
  3. Altered biological activity associated with C-terminal modifications of IL-7. Görgün, G., van der Spek, J., Cosenza, L., Menevse, A., Foss, F. Cytokine (2002) [Pubmed]
 
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