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Chemical Compound Review:

CHEMBL176837 (E)-3-(6-aminopurin-9- yl)prop-2-enal

Synonyms: CCRIS 8712, AC1O5QUK, LS-123220, AKOS006274731, 90029-73-5, ...

Berhane, K. et al.

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Disease relevance of Adenine propenal

GST P1-1 added to the culture medium of HeLa cells augmented the protective effect of glutathione against the toxicity of adenine propenal and thymine propenal [1].

High impact information on Adenine propenal

The catalytic efficiency of GST P1-1 with adenine propenal (kcat/Km = 7.7 x 10(5) M-1.s-1) is the highest so far reported with any substrate for this enzyme [1].

Associations of Adenine propenal with other chemical compounds

GST P1-1 was particularly active in catalyzing the reactions with the propenal derivatives, and adenine propenal was the substrate giving the highest activity [1].

References

Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases. Berhane, K., Widersten, M., Engström, A., Kozarich, J.W., Mannervik, B. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]

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