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Chemical Compound Review

Azepane     azepane

Synonyms: azepan, Homopiperidine, SureCN26492, HSDB 562, CCRIS 8886, ...
 
 
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Disease relevance of azepane

 

High impact information on azepane

  • Novel azepane derivatives were prepared and evaluated for protein kinase B (PKB-alpha) and protein kinase A (PKA) inhibition [2].
  • Structure-based optimization of novel azepane derivatives as PKB inhibitors [2].
  • Key transformations include a Staudinger-aza-Wittig reaction to form the central perhydroazepine ring system and an iodine-induced tandem cyclization to construct the pyrrolidino-butyrolactone framework [3].
  • In a single-blind study of several doses of a new hexahydroazepine analgesic, meptazinol, in 45 patients recovering from major abdominal surgery, there was a dose-related significant analgesic effect from i.m. doses exceeding 50 mg [4].
 

Analytical, diagnostic and therapeutic context of azepane

References

  1. Preferential inhibition of ribonucleic acid synthesis by a new thiosemicarbazone possessing antibacterial and antiparasitic properties. Brown, R.E., Stancato, F.A., Wolfe, A.D. Antimicrob. Agents Chemother. (1981) [Pubmed]
  2. Structure-based optimization of novel azepane derivatives as PKB inhibitors. Breitenlechner, C.B., Wegge, T., Berillon, L., Graul, K., Marzenell, K., Friebe, W.G., Thomas, U., Schumacher, R., Huber, R., Engh, R.A., Masjost, B. J. Med. Chem. (2004) [Pubmed]
  3. Total synthesis of (-)-stemonine. Williams, D.R., Shamim, K., Reddy, J.P., Amato, G.S., Shaw, S.M. Org. Lett. (2003) [Pubmed]
  4. Clinical evaluation of meptazinol. a new analgesic, in postoperative pain. Paymaster, N.J. British journal of anaesthesia. (1976) [Pubmed]
  5. Intramuscular meptazinol analgesia after surgery: a study of the dose-response effect and a controlled comparison with pentazocine and pethidine. Paymaster, N.J. Postgraduate medical journal. (1983) [Pubmed]
 
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