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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ARPC2  -  actin related protein 2/3 complex, subunit...

Homo sapiens

Synonyms: ARC34, Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34 kDa subunit, PNAS-139, PRO2446, ...
 
 
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Disease relevance of ARPC2

 

High impact information on ARPC2

  • Subunits ARPC2 p34 and ARPC4 p20 in the core of the complex associate through long carboxyl-terminal alpha helices and have similarly folded amino-terminal alpha/beta domains [2].
  • MLN64 overexpression increased the number of actin and p34-Arc-positive patches on late endosomes, enhanced the fusion of late endocytic organelles in an actin-dependent manner, and stimulated the deposition of sterol in late endosomes harboring the protein [3].

References

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. Welch, M.D., DePace, A.H., Verma, S., Iwamatsu, A., Mitchison, T.J. J. Cell Biol. (1997) [Pubmed]
  2. Crystal structure of Arp2/3 complex. Robinson, R.C., Turbedsky, K., Kaiser, D.A., Marchand, J.B., Higgs, H.N., Choe, S., Pollard, T.D. Science (2001) [Pubmed]
  3. MLN64 is involved in actin-mediated dynamics of late endocytic organelles. Hölttä-Vuori, M., Alpy, F., Tanhuanpää, K., Jokitalo, E., Mutka, A.L., Ikonen, E. Mol. Biol. Cell (2005) [Pubmed]
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