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Gene Review:

ACTR1B - ARP1 actin-related protein 1 homolog B,...

Homo sapiens

Synonyms: ARP1B, Actin-related protein 1B, Beta-centractin, CTRN2, PC3

Clark, S.W. et al., Elsea, S.H. et al.

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High impact information on ACTR1B

The full-length cDNA clone isolated using the expressed sequence tag encodes a new member of the centractin family, beta-centractin [1].
Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1-->q11.2 with somatic cell hybrids and in situ hybridization [2].

Biological context of ACTR1B

The amino acid sequence of beta-centractin, deduced from the cDNA, indicates a 91% identity with alpha-centractin, increasing to 96% similarity when conservative amino acid changes are taken into account [1].

Analytical, diagnostic and therapeutic context of ACTR1B

As antibodies previously raised against alpha-centractin reacted only poorly with beta-centractin, new antibodies were produced and combined with two-dimensional gel electrophoresis to discriminate the two isoforms [1].
Comparisons of Northern blots of human tissues indicated that alpha-centractin and beta-centractin mRNAs are equally distributed in all populations of mRNA examined, whereas the expression of gamma-centractin appears to be tissue specific [1].

References

Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. Clark, S.W., Staub, O., Clark, I.B., Holzbaur, E.L., Paschal, B.M., Vallee, R.B., Meyer, D.I. Mol. Biol. Cell (1994) [Pubmed]
Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1-->q11.2 with somatic cell hybrids and in situ hybridization. Elsea, S.H., Clark, I.B., Juyal, R.C., Meyer, D.J., Meyer, D.I., Patel, P.I. Cytogenet. Cell Genet. (1999) [Pubmed]

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ACTR1B	Bos taurus
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actr1	Danio rerio
KLLA0E22925g	Kluyveromyces lactis NRRL Y-1140
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MGG_16793	Magnaporthe oryzae 70-15
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NCU04247	Neurospora crassa OR74A
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ARP1	Saccharomyces cerevisiae S288c
arp1	Schizosaccharomyces pombe 972h-

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