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Gene Review

LINC01587  -  long intergenic non-protein coding RNA 1587

Homo sapiens

Synonyms: AC1, C4orf6, Protein AC1, Uncharacterized protein C4orf6, aC1
 
 
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Disease relevance of C4orf6

  • A novel bacteriophage, termed phi AC1, that infects strains of the genus Acidiphilium (acidophilic, heterotrophic, aerobic, Gram-negative eubacteria) most commonly isolated from acidic mine drainage environments, has been discovered and several of its properties have been determined [1].
  • Measured global EF values in 14 patients without coronary stenosis were 52.3% +/- 7.6% (AC1), 60.6% +/- 8.9% (AC2) and 55.6% +/- 5.6% (AC3), and those in 11 patients with severe ischaemia were 53.6% +/- 8.0% (AC1), 45.6% +/- 12.1% (AC2) and 49.7% +/- 10.7% [2].
 

High impact information on C4orf6

  • The AC1 channel can be activated from the intracellular side by protein kinase C activators such as diacylglycerol and phorbolester and by cGMP but not by Ca2+, inositol 1,4,5-triphosphate, or cAMP [3].
  • Surprisingly, serotonin activation of 5-HT7A stimulated AC1 and AC8 by increasing intracellular Ca2+ [4].
  • Gene disruption studies have shown that the Ca(2+)-stimulated adenylyl cyclases, AC1 and AC8, are critical for some forms of synaptic plasticity, including long-term potentiation as well as long-term memory formation (LTM) [5].
  • In contrast to AC1 and AC8, AC3 is a Ca(2+)-inhibited adenylyl cyclase that plays an essential role in olfactory signal transduction [5].
 

Analytical, diagnostic and therapeutic context of C4orf6

  • Comparing sequences of ORF2 of different HAstV serotypes, we established a rapid and highly sensitive detection system for HAstV types using RT-PCR with the AC230/AC1' primer set designed from the 5'-terminal end region of ORF2 [6].
  • This RT-PCR system seems very useful in detecting at least two different viruses in a single PCR test tube using AC230/AC1' in addition to the NV81/82, SM82 primer sets [6].

References

  1. Characterization of a new bacteriophage which infects bacteria of the genus Acidiphilium. Ward, T.E., Bruhn, D.F., Shean, M.L., Watkins, C.S., Bulmer, D., Winston, V. J. Gen. Virol. (1993) [Pubmed]
  2. Gated single-photon emission tomography imaging protocol to evaluate myocardial stunning after exercise. Hashimoto, J., Kubo, A., Iwasaki, R., Iwanaga, S., Mitamura, H., Ogawa, S., Kosuda, S. European journal of nuclear medicine. (1999) [Pubmed]
  3. Dual activation of a sex pheromone-dependent ion channel from insect olfactory dendrites by protein kinase C activators and cyclic GMP. Zufall, F., Hatt, H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor. Baker, L.P., Nielsen, M.D., Impey, S., Metcalf, M.A., Poser, S.W., Chan, G., Obrietan, K., Hamblin, M.W., Storm, D.R. J. Biol. Chem. (1998) [Pubmed]
  5. Calmodulin-regulated adenylyl cyclases: cross-talk and plasticity in the central nervous system. Wang, H., Storm, D.R. Mol. Pharmacol. (2003) [Pubmed]
  6. Genomic characterization of human astrovirus type 6 Katano virus and the establishment of a rapid and effective reverse transcription-polymerase chain reaction to detect all serotypes of human astrovirus. Sakon, N., Yamazaki, K., Utagawa, E., Okuno, Y., Oishi, I. J. Med. Virol. (2000) [Pubmed]
 
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