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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DPYSL4  -  dihydropyrimidinase-like 4

Homo sapiens

Synonyms: CRMP-3, CRMP3, Collapsin response mediator protein 3, DRP-4, Dihydropyrimidinase-related protein 4, ...
 
 
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Disease relevance of DPYSL4

 

High impact information on DPYSL4

  • Serum IgG in all cases bound to recombinant CRMP-5 (predominantly N-terminal epitopes), but not to human CRMP-2 or CRMP-3 [2].
  • Here we report the identification of a novel CRMP3-associated protein, designated CRAM for CRMP3-associated molecule, that belongs to the unc-33 gene family [3].
  • Indeed, CRAM physically associates with CRMP3 when co-expressed in COS-7 cells [3].

References

  1. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Honnorat, J., Byk, T., Kusters, I., Aguera, M., Ricard, D., Rogemond, V., Quach, T., Aunis, D., Sobel, A., Mattei, M.G., Kolattukudy, P., Belin, M.F., Antoine, J.C. Eur. J. Neurosci. (1999) [Pubmed]
  2. CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Yu, Z., Kryzer, T.J., Griesmann, G.E., Kim, K., Benarroch, E.E., Lennon, V.A. Ann. Neurol. (2001) [Pubmed]
  3. Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain. Inatome, R., Tsujimura, T., Hitomi, T., Mitsui, N., Hermann, P., Kuroda, S., Yamamura, H., Yanagi, S. J. Biol. Chem. (2000) [Pubmed]
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