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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Krt9  -  keratin 9

Mus musculus

Synonyms: CK-9, Cytokeratin-9, EPPK, K9, Keratin, type I cytoskeletal 9, ...
 
 
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Disease relevance of Krt9

  • Thus, the K9 gene of KSHV encodes the first virus-encoded IRF (v-IRF) which functions as a repressor for cellular IFN-mediated signal transduction [1].
 

High impact information on Krt9

  • Expression of K9 dramatically repressed transcriptional activation induced by IFN-alpha, -beta, and -gamma [1].
  • We have investigated the functional consequence of K9 expression in IFN-mediated signal transduction [1].
  • The K9 open reading frame of Kaposi's sarcoma-associated herpesvirus (KSHV) exhibits significant homology with cellular IFN regulatory factors (IRFs) [1].
  • Keratin 9 (K9) is one of the components of the perinuclear ring of the manchette found in developing spermatids but is predominantly expressed in the epidermis of the footpad (palm and sole in human epidermis) [2].
  • Surprisingly, in oocyte nuclear injection experiments using K9(neo/neo) sperm donor, 76% of the resulting animals displayed a deletion of the neo(r) gene from the intron 6 of the mutated K9 allele [2].
 

Biological context of Krt9

  • In addition, the open reading frame of the aberrant mRNA terminated at the exon 6/intron 6 splice site, resulting in a truncated K9 protein [2].

References

  1. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor. Li, M., Lee, H., Guo, J., Neipel, F., Fleckenstein, B., Ozato, K., Jung, J.U. J. Virol. (1998) [Pubmed]
  2. Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene. Rivkin, E., Eddy, E.M., Willis, W.D., Goulding, E.H., Suganuma, R., Yanagimachi, R., Kierszenbaum, A.L. Mol. Reprod. Dev. (2005) [Pubmed]
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