Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

CCDC85B - coiled-coil domain containing 85B

Homo sapiens

Synonyms: Coiled-coil domain-containing protein 85B, DIPA, Delta-interacting protein A, Hepatitis delta antigen-interacting protein A

Bezy, O. et al., Tutus, A. et al., Du, X. et al., Murayama, M., Chang, J. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CCDC85B

Delta-interacting protein A and the origin of hepatitis delta antigen [1].
It is concluded that Tc-99m DIPA cholescintigraphy may be helpful in the diagnosis of Rotor syndrome [2].

High impact information on CCDC85B

DNA sequence analysis revealed that this protein, termed delta-interacting protein A (DIPA), is a cellular homolog of HDAg [3].
DIPA mRNA is expressed during adipocyte differentiation of clonal cell lines [4].
In an attempt to identify novel proteins that interact with C/EBP beta, we performed a yeast two-hybrid screen with a preadipocyte cDNA library and identified a new co-regulator, delta-interacting protein A (DIPA) [4].
Stable overexpression of DIPA in preadipocytes partially inhibits adipocyte differentiation, whereas its gene silencing enhances this process [4].
Thus, DIPA is a novel partner of C/EBP beta that down-regulates early events of adipogenesis [4].

Chemical compound and disease context of CCDC85B

A 2-year-old boy with Rotor syndrome was studied with Tc-99m N-(di-isopropylphenyl carbamoylmethyl) iminodiacetic acid (DIPA) [2].

Biological context of CCDC85B

DIPA (decompression-inducible platelet aggregation) and hemostasis: vascular occlusion and its prevention, in the web of the frog's foot [5].

Anatomical context of CCDC85B

Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation [4].
In addition, a fraction of DIPA can be detected on the centrosome [6].
Two cases of large gallbladder stones, demonstrated by Tc-99m DIPA scintigraphy are presented [7].

Associations of CCDC85B with chemical compounds

The ruthenium-bound dipa ligand possesses structural constraints that prevent the usual oxidative dehydrogenation reaction, which would yield exclusively the corresponding imine [8].
When experimental pressure is 253 torr (as at the top of Mt. Everest): (1) DIPA takes place independently of PO2; (2) ex vivo DIPA can be inhibited by menthol, thymol, piracetam and pentoxifylline [9].

Analytical, diagnostic and therapeutic context of CCDC85B

We analyzed the interaction between DIPA and p78 by co-immunoprecipitation and identified the structural regions involved in the interaction [6].

References

Delta-interacting protein A and the origin of hepatitis delta antigen. Long, M., de Souza, S.J., Gilbert, W. Science (1997) [Pubmed]
Cholescintigraphy in the diagnosis of Rotor syndrome. Tutus, A., Silov, G., Kula, M. Clinical nuclear medicine. (1997) [Pubmed]
A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. Brazas, R., Ganem, D. Science (1996) [Pubmed]
Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. Bezy, O., Elabd, C., Cochet, O., Petersen, R.K., Kristiansen, K., Dani, C., Ailhaud, G., Amri, E.Z. J. Biol. Chem. (2005) [Pubmed]
DIPA (decompression-inducible platelet aggregation) and hemostasis: vascular occlusion and its prevention, in the web of the frog's foot. Murayama, M. Thromb. Res. (1989) [Pubmed]
DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. Du, X., Wang, Q., Hirohashi, Y., Greene, M.I. Exp. Mol. Pathol. (2006) [Pubmed]
Visualization of gallstones by hepatobiliary scintigraphy. Two case reports. Garty, I. Clinical nuclear medicine. (1984) [Pubmed]
Synthesis and characterization of bis(di-2-pyridylmethanamine)ruthenium(II). Chang, J., Plummer, S., Berman, E.S., Striplin, D., Blauch, D. Inorganic chemistry. (2004) [Pubmed]
AMS (acute mountain sickness), a vascular occlusive disease. Murayama, M. Med. Hypotheses (1990) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

CCDC85B	Canis lupus familiaris
ccdc85b	Danio rerio
CCDC85B	Macaca mulatta
Ccdc85b	Mus musculus
CCDC85B	Pan troglodytes
Ccdc85b	Rattus norvegicus
ccdc85b	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.