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Gene Review

Char1  -  P. chabaudi malaria resistance QTL 1

Mus musculus

 
 
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Disease relevance of Char1

 

High impact information on Char1

  • Recombinant congenic strains AcB55 and AcB61 are unusually resistant to malaria despite carrying susceptibility alleles at Char1 and Char2 [2].
  • The Char1 locus ( P. chabaudi resistance locus 1), controlling host survival and peak parasitemia in P. chabaudi infection, was previously mapped to the same region [3].

References

  1. Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice. Fortin, A., Cardon, L.R., Tam, M., Skamene, E., Stevenson, M.M., Gros, P. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Pyruvate kinase deficiency in mice protects against malaria. Min-Oo, G., Fortin, A., Tam, M.F., Nantel, A., Stevenson, M.M., Gros, P. Nat. Genet. (2003) [Pubmed]
  3. Chromosomal mapping of the host resistance locus to rodent malaria (Plasmodium yoelii) infection in mice. Ohno, T., Ishih, A., Kohara, Y., Yonekawa, H., Terada, M., Nishimura, M. Immunogenetics (2001) [Pubmed]
 
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