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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLC25A25  -  solute carrier family 25 (mitochondrial...

Homo sapiens

Synonyms: APC3, Calcium-binding mitochondrial carrier protein SCaMC-2, KIAA1896, MCSC, MCSC3, ...
 
 
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High impact information on SLC25A25

  • SCaMC-1 is the human orthologue of the rabbit Efinal protein, which was reported to be located in peroxisomes, and SCaMC-2 is the human orthologue of the rat MCSC protein, described as up-regulated by dexamethasone in AR42J cells [1].
  • In the liver, the expression level of MCSC was higher in the adult stage than in the fetal stage, and MCSC was highly up-regulated in dexamethasone-treated AR42J cells before the expression of albumin [2].
  • Taken together, MCSC may play an important role in regulating the function of hepatocytes rather than in differentiation in vivo [2].
 

Analytical, diagnostic and therapeutic context of SLC25A25

  • Using mRNA differential display techniques, we have identified a novel Ca2+-dependent member of the mitochondrial solute carrier superfamily, which is expressed during the course of differentiation, and have designated it MCSC [2].

References

  1. Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains. del Arco, A., Satrústegui, J. J. Biol. Chem. (2004) [Pubmed]
  2. A novel mitochondrial Ca2+-dependent solute carrier in the liver identified by mRNA differential display. Mashima, H., Ueda, N., Ohno, H., Suzuki, J., Ohnishi, H., Yasuda, H., Tsuchida, T., Kanamaru, C., Makita, N., Iiri, T., Omata, M., Kojima, I. J. Biol. Chem. (2003) [Pubmed]
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