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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CLTA  -  clathrin, light chain A

Homo sapiens

Synonyms: Clathrin light chain A, Lca
 
 
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High impact information on CLTA

  • In contrast, clathrin light chain genes (CLTA and CLTB) apparently arose by localized duplication, within 1-11 million years of CHC gene duplication [1].
  • The gene (CLTA) encoding the LCa light chain maps to the long arm of chromosome 12 at 12q23-q24 and that encoding the LCb light chain (CLTB) maps to the long arm of chromosome 4 at 4q2-q3 [2].
  • Tests of homogeneity in the distribution of individual alleles at Lca 43 gave similar results: one low frequency allele was distributed heterogeneously among samples before, but not after, Bonferroni correction [3].
  • Allele distribution at microsatellite Lca 43 was heterogeneous among localities before (but not after) Bonferroni corrections for multiple tests executed simultaneously [3].
  • Polyclonal antisera generated through position 17 reacted preferentially with 4-chlorotestosterone-17-acetate (clostebol acetate, CLTA), 4-chloro-epitestosterone (epi-clostebol, 17alpha-clostebol, 17alpha-CLT), and clostebol, whereas polyclonal antisera generated through the 3 position almost did not react with these derivatives [4].

References

  1. Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution. Wakeham, D.E., Abi-Rached, L., Towler, M.C., Wilbur, J.D., Parham, P., Brodsky, F.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB). Ponnambalam, S., Jackson, A.P., LeBeau, M.M., Pravtcheva, D., Ruddle, F.H., Alibert, C., Parham, P. Genomics (1994) [Pubmed]
  3. Microsatellite variation among red snapper (Lutjanus campechanus) from the Gulf of Mexico. Gold, J.R., Pak, E., Richardson, L.R. Mar. Biotechnol. (2001) [Pubmed]
  4. Influence of the hapten conjugation site on the characteristics of antibodies generated against metabolites of clostebol acetate. Crabbe, P., Van Peteghem, C., Salden, M., Kohen, F. J. Agric. Food Chem. (2000) [Pubmed]
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