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Zfp36l1  -  zinc finger protein 36, C3H type-like 1

Mus musculus

Synonyms: AW742437, AW743212, Berg36, Brf1, Butyrate response factor 1, ...
 
 
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High impact information on Zfp36l1

  • TIS11, TIS11b, and TIS11d proteins share a 67-amino-acid region of sequence similarity that includes the YKTELC repeat and two cysteine-histidine containing repeats [1].
  • Induction of TNFalpha mRNA by lipopolysaccharide was significantly inhibited when TIS11B was overexpressed [2].
  • However, in contrast to genes such as c-fos and TIS11, cMG1 is also expressed at significant levels before and after the transient elevation induced by agonists [3].
  • We have sequenced a 1.3 kb rat genomic cMG1 clone, which includes 931 bp upstream of the transcription start site identified by primer-extension analysis [3].
  • VEGF-A overproduction by embryonic fibroblasts was not a consequence of changes in Vegf-a mRNA stability; instead, we observed enhanced association with polyribosomes, suggesting Zfp36l1 influences translational regulation [4].
 

Biological context of Zfp36l1

  • TTP, TIS11b, and TIS11d each also induce apoptosis through the mitochondrial pathway analogously to certain oncogenes, suggesting that they influence growth or survival signals [5].
  • This effect seems to require only the conserved TTP zinc finger region, and is characteristic of the related proteins TIS11b and TIS11d [5].
  • The Zfp36l1 gene encodes a zinc finger-containing mRNA binding protein implicated in the posttranscriptional control of gene expression [4].
  • cMG1 is a primary response gene first identified in a rat intestinal epithelial (RIE-1) cell-line [(1990) Oncogene 5, 1081-1083] [6].
 

Anatomical context of Zfp36l1

  • Mitogen-induced expression of the primary response gene cMG1 in a rat intestinal epithelial cell-line (RIE-1) [6].
 

Other interactions of Zfp36l1

  • The effects of TIS11B on TNFalpha expression were examined using an overexpression model of TIS11B in RAW264.7 cells [2].
 

Analytical, diagnostic and therapeutic context of Zfp36l1

  • Ribonucleoprotein (RNP) complex immunoprecipitation experiments allowed us to demonstrate that the interaction between TIS11b and VEGF 3'-untranslated region occurs in live cells [7].

References

  1. The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Varnum, B.C., Ma, Q.F., Chi, T.H., Fletcher, B., Herschman, H.R. Mol. Cell. Biol. (1991) [Pubmed]
  2. Butyrate suppresses tumor necrosis factor alpha production by regulating specific messenger RNA degradation mediated through a cis-acting AU-rich element. Fukae, J., Amasaki, Y., Yamashita, Y., Bohgaki, T., Yasuda, S., Jodo, S., Atsumi, T., Koike, T. Arthritis Rheum. (2005) [Pubmed]
  3. Identification of a functional promoter element in the 5'-flanking region of the rat cMG1/TIS11b gene. Corps, A.N., Pascall, J.C., Hadfield, K.M., Brown, K.D. Biochem. J. (1995) [Pubmed]
  4. The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Bell, S.E., Sanchez, M.J., Spasic-Boskovic, O., Santalucia, T., Gambardella, L., Burton, G.J., Murphy, J.J., Norton, J.D., Clark, A.R., Turner, M. Dev. Dyn. (2006) [Pubmed]
  5. Multiple tristetraprolin sequence domains required to induce apoptosis and modulate responses to TNFalpha through distinct pathways. Johnson, B.A., Blackwell, T.K. Oncogene (2002) [Pubmed]
  6. Mitogen-induced expression of the primary response gene cMG1 in a rat intestinal epithelial cell-line (RIE-1). Gomperts, M., Corps, A.N., Pascall, J.C., Brown, K.D. FEBS Lett. (1992) [Pubmed]
  7. Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. Ciais, D., Cherradi, N., Bailly, S., Grenier, E., Berra, E., Pouyssegur, J., Lamarre, J., Feige, J.J. Oncogene (2004) [Pubmed]
 
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