Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

DEFB127 - defensin, beta 127

Homo sapiens

Synonyms: Beta-defensin 127, Beta-defensin 27, C20orf73, DEF-27, DEFB-27, ...

Schulz, A. et al.

Schulz, Klüver, Schulz-Maronde, Adermann,

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High impact information on DEFB127

While hBD-27 was readily converted into a product with the desired disulfide pattern by oxidative folding, hBD-28 required a selective protective group strategy to introduce the three disulfide bonds [1].
Compared to the other peptides tested, hBD-27 showed almost no cytotoxic activity, measured by hemoglobin release of erythrocytes [1].

Analytical, diagnostic and therapeutic context of DEFB127

Determination of the minimum inhibitory concentration against different bacteria revealed that hBD-27, in contrast to other beta-defensins tested, has virtually no antimicrobial activity [1].

References

Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. Schulz, A., Klüver, E., Schulz-Maronde, S., Adermann, K. Biopolymers (2005) [Pubmed]

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