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Gene Review

Fzd3  -  frizzled homolog 3 (Drosophila)

Mus musculus

Synonyms: AU020229, D930050A07Rik, Frizzled-3, Fz-3, Fz3, ...
 
 
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High impact information on Fzd3

  • An aberrant U-shaped fiber bundle immediately caudal to the optic tract connects the left and right sides of the Fz3(-/-) thalamus and likely represents a default pathway for thalamic axons that failed to enter the internal capsule [1].
  • Previous work has identified axonal outgrowth and/or guidance defects in the brain and spinal cord of prenatal Frizzled3 (Fz3)(-/-) mice [1].
  • (2002), we find that the following structures/tracts are absent or greatly reduced in the Fz3(-/-) brain: the anterior commissure, cerebral peduncle (corticospinal tract), corpus callosum, fornix, internal capsule (thalamocortical and corticothalamic tracts), stria medullaris, stria terminalis, and hippocampal commissure [1].
  • Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals [2].

References

  1. Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling. Wang, Y., Zhang, J., Mori, S., Nathans, J. J. Neurosci. (2006) [Pubmed]
  2. Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. Montcouquiol, M., Sans, N., Huss, D., Kach, J., Dickman, J.D., Forge, A., Rachel, R.A., Copeland, N.G., Jenkins, N.A., Bogani, D., Murdoch, J., Warchol, M.E., Wenthold, R.J., Kelley, M.W. J. Neurosci. (2006) [Pubmed]
 
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