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Gene Review

LAYN  -  layilin

Homo sapiens

Synonyms: FLJ30977, FLJ31092, Layilin, UNQ208/PRO234
 
 
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High impact information on LAYN

  • Layilin's ability to bind hyaluronan, a ubiquitous extracellular matrix component, reveals an interesting parallel between layilin and CD44, because both can bind to cytoskeleton-membrane linker proteins through their cytoplasmic domains and to hyaluronan through their extracellular domains [1].
  • This parallelism suggests a role for layilin in cell adhesion and motility [1].
  • Furthermore, layilin antibody can immunoprecipitate merlin, confirming association in vivo between these two proteins, which also display similar subcellular localizations in ruffling membranes [2].

References

  1. Layilin, a novel integral membrane protein, is a hyaluronan receptor. Bono, P., Rubin, K., Higgins, J.M., Hynes, R.O. Mol. Biol. Cell (2001) [Pubmed]
  2. Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. Bono, P., Cordero, E., Johnson, K., Borowsky, M., Ramesh, V., Jacks, T., Hynes, R.O. Exp. Cell Res. (2005) [Pubmed]
 
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