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Gene Review

PPP4R2  -  protein phosphatase 4, regulatory subunit 2

Homo sapiens

Synonyms: SBBI57, Serine/threonine-protein phosphatase 4 regulatory subunit 2
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Disease relevance of PPP4R2


High impact information on PPP4R2

  • The encoded putative PPP4 regulatory subunit (termed PPP4R2), comprising 453 amino acids, had a molecular mass of 50.4 kDa [1].
  • Immunocytological detection of PPP4R2 at centrosomes suggests that it may target PPP4c to this location [1].
  • The interaction of PPP4R2 with PPP4 catalytic subunit (PPP4c) was confirmed by co-sedimentation of PPP4c with PPP4R2 expressed in bacteria and human cells [1].
  • Native 450 kDa and 600 kDa PPP4 complexes are inactive, but can be activated by basic proteins, suggesting that PPP4R2 may also regulate the activity of PPP4c at centrosomal microtubule organising centres [1].


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